Increased transendothelial channel transport of cerebral capillary endothelium in stroke-prone SHR.
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چکیده
منابع مشابه
Increased transendothelial channel transport of cerebral capillary endothelium in stroke-prone SHR.
Permeability of brain capillaries of stroke-prone spontaneously hypertensive rats (SHRSP) was studied using labelling (horseradish peroxidase) and cytochemical techniques at the cellular level. In the cerebral capillary endothelium the tracer molecules were quickly transported by abundant transendothelial channels which directly connected the capillary lumen to the subendothelial space. Transen...
متن کاملGenetic subgrouping of stroke-prone SHR and stroke-resistant SHR.
From these results, we can conclude that the developmental pattern of hypertension in the young age is genetically determined and closely related to the incidence of hemorrhage or infarction. These newly selected substrains of SHRSP with higher incidences of cerebral infarction (SP-2) or hemorrhage (SP-1) are regarded as the better models for studying the pathogenesis, treatment, and prevention...
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Dopamine and norepinephrine fluorescence in the nucleus caudatus and putamen and cerebral cortex was markedly depleted along with rCBF reduction in symptomatic stroke-prone spontaneously hypertensive rats (SHRSP) with bilateral carotid artery ligatioa under light pentobarbital anesthesia. An accumulation of fluorescence at the intima of blood Teasels, especially in the nucleus caudatus and puta...
متن کاملPermeability of intracranial extracerebral vessels in stroke-prone SHR.
Permeability of intracranial extracerebral arteries of stroke-prone spontaneously hypertensive rats (SHRSP) was studied using labeling techniques (ferritin and horseradish peroxidase), at the cellular level. In the arterial endothelial cells, the tracer molecules were slowly but constantly transported by the plasmalemmal vesicles to the subendothelial space. This endothelial transportation of t...
متن کاملEffect of acute arterial hypertension in stroke-prone and stroke-resistant SHR.
Acute transient hypertension by norepinephrine was loaded to stroke-resistant (SHRSR), stroke-prone (SHRSP), and normotensive Wistar Kyoto (WK) rats. (SHRSP were most sensitive to norepinephrine in young pre-hypertensive group.) Its effects on cerebral small vessels were studied using Evans Blue to detect the increase of vascular permeability. Severe macroscopic dye-leakages were observed in th...
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ژورنال
عنوان ژورنال: Stroke
سال: 1983
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.14.4.591